Ok.
Well, I wouldn't rise light samples at all, I use HDRi for 90perc. of my jobs and I only rise LS for interiors with lot of artificial lights. You will still fight mostly GI and AA.
PT+PT for glossy interior is really bad choice, HDCache outside of GI, also helps with glossy materials. You can use it, but it will take hours, and will give negliably only better image.
I have no idea about multi-sub mats, I am interested too in that.