Are you making some extreme changes to your lights with LightMix? For example, changing light intensity from 1 to 100 or from 100 to 1?
If that's the case, then this issue would be expected and what you see is the way Corona samples lights. If a light is weak and does not contribute much to the overall scene lighting, it will receive less samples. If you boost that light's intensity with LightMix, then you will see that it received less samples.
To avoid this, try to make only subtle adjustments with LightMix (do not use extremely high or low values).
Additionally, once you are happy with your LightMix setup, you can press the ">Scene" button in the VFB > LightMix tab and this will bake your LightMix values into all your scene lights. Once you re-render, you should not be getting these noise issues any more, but note that this action cannot be undone!