Well, 7-8 hours with that much noise is bs ;]
Use UHD cache, it will help incredibly cleaning up interior with HDRI. Portals are optional, dont obsess over them.
MSI@50 is too high. At that point you might aswell turn on unbiased mode.
Try to 15 or even 10 instead. You have no caustics and brightness loss will be onl measureable, not visible.
It will help alot, if you have a bright patch of hdri, bashing little reflective rays into the far sides of the interiour, that may not cleanup even after hours.
You seem to have a strong shadow, if it's from the HDRI, then portals wont help at all, as its not very good with sharp very bright spots on the hdri dome.