Use with caution !
Is it because of its unnaturalness, or is there some other hidden issues?
No..it's because there are many ways architect, developer, and you, can be sued for deceit ;- ). It can be argued that wide-angle is more deceiving that longer focal length hidden behind wall, but both can be taken to extreme and really create wrongful illusion. In US/UK that can get you in trouble.
But also lately, after visiting some real locations, I am not sure I can say that here...but I almost felt guilty how much better I made it look in CGI... so now I am committed to not taking illusion very far. Architecture should be portrayed like it will exists, at least that is my current position. I don't hide or fake things when clients ask me now.
Architect: "We need to make this box room look big..."
Artist: "Ok. (Sets camera to 18mm) This ok?"
Architect: "No, it needs to look bigger"
Artist: "Erm, ok. (Sets camera to 12mm :S). How about this?"
Architect: "Go lower, we need to see everything and it needs to look big".
Artist: "Lower? Erm i er..."
Architect: "WHY DOES EVERYTHING LOOK SO DISTORTED!?"