Everything reverts when disabling tweak mode again. So if you have been running IR before pressing the button, IR would continue running after tweaking. If it was not running, IR is stopped after using the button. This is by purpose and kind of principle of the script: You break out of the prison of your scene with overrides, strange tone mapping settings+LUT and incredible exposure with one click to tweak in a defined environment and are exactly there where you have been when switching back. But of course this can be configured by a parameter (which would act like described by default), will consider.
Good Luck