Since 48GB DIMMs are very recent, there will be almost no one to tell you if it works or not. It technically should, but there are possible complications:
1) bios recognition, check if your chosen motherboard had recent bios update offered on website, and if it perhaps mentions support for the new module size.
2) mainstream platforms, particularly AMD, does struggle with lot of memory. Even 128GB seems to be hard to run at XMP profile, so be prepared for manual settings if the system won't boot or run stable at 5200 CL18. You might need to lower it to 4800 CL38 or less.
Anyway, I am definitely interested in your experience, 48GB DDR5 DIMMs are fantastic thing, even small 2-dimm ITX boards can now have 96GB ram. So let us know how it goes.