Regular image has exposure locked in, which you must to match more or less closely in your scene, but with HDRI you have much more freedom to change exposure for your needs. As for RAM usage, same goes for all the assets in your scene - if you have enough RAM, you don't have to worry about a thing, but if you're thin on RAM, then you have to think about optimizations. For me it's almost always scenario No. 2 :]