Hi Toby,
You don't need to uses "CoronaMix Texture" node in C4D, because you already have the "Layer" option. You'll find by clicking on the arrow next to the map slot. It's very complete and has different type of blending too.
For the IOR map generated by Substance Designer, you need to set the highest IOR value you want on your material.
Example: I designed a Chrome with dirt on it in Substance Designer > In Corona, I put 20-50 in the IOR value (for chrome) of my standard Material, then I input the IOR map generated by Substance Designer in the texture slot, it will decrease the value of the IOR where the dirt appears. (Chrome ~ 20 -50 / Dirt ~ 1.4)
IOR map > White = 100% IOR value / Black = 0% IOR Value.
Hope this answer suits your questions.
Cheers