There is quite some interior, as seen by looking into the buildings, so use UHD Cache for secondary, it will still use PT+PT for outside, but UHD Cache for inside.
Unless it's some weird motionblur: it seems that the roof and the stairs on of the building the right have Z-dapth fighting. (Two surfaces, perfectly intersecting each other)
This can cause Splotches and random noise, as it becomes random, which surface a ray hits. Zdepth fighting has to be always avoided.
Lastly 5 passes 50% Denoise is quite the thing. If you gonna use such low render settings, don't use MotionBlur, as it will look aweful and 5 passes motion blur, will never look right. You can always try post processed motionblur, like ReelSmartMotionBlur for after effects. (infact, after effects even has a built in feature)