I recently did a job with a ton of detail and a huuuuge size (for a close up 7.5m wall print).
Ended up rendering it out in 30.000px x 15.000px
Now that was an exercise! (and a headache), but the solution at the end was using Deadline's tile rendering and outputting 1125 smaller tiles (due to memory problems with 16-32gb), and then stitching it all back together in Nuke.
I can't remember if I ended up keeping internal res 2 or not but I will try and post some images sometime soon.
I could be wrong, but in theory, keeping internal resolution 2 when there will be stitching later doesn't seem good idea since the anti-alias will happen only inside each tile, but not on borders (since the tile can't be aware of its neighbors). Maybe the visual difference would be small, maybe it would produce slight aliased grid along the merges borders of tiles... I don't know. Just my understanding, could be completely wrong..
You could be very right, and I did end up using an internal res value of "1" because it was an exercise of memory usage, so did it naturally (maybe a bit lucky even).
anyway due to the size of the render and project, the amount of detail needed was absurd.
fun facts:
Max file size: 1.847GB
Photoshop file size: 17GB
Jpeg output (quality 12 from PS): 340mb
16bit Tiff output (from PS): 870mb
on a machine with 32GB of ram, it took about 35mins to save the PS file during post production.